A mathematical model for cell cycle control: graded response or quantized response

• Published in: Cell cycle (Georgetown, Tex.) Vol. 21; no. 8; pp. 820 - 834
• Main Authors: Wu, Guoyu, Xiu, Huiyu, Luo, Haiying, Ding, Yu, Li, Yuchao
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 18.04.2022
• Subjects: Cell Cycle; Cell cycle arrest; Cell Cycle Checkpoints; Cell Division; Inheritable quiescence; Mathematical model; Models, Theoretical; Multiple stimulations; Refractory state; Research Paper; Cell cycle arrest; Inheritable quiescence; Multiple stimulations; Mathematical model; Refractory state
• ISSN: 1538-4101; 1551-4005
• DOI: 10.1080/15384101.2022.2031770

Cell cycle is an important and complex biological system. A lot of efforts have been put in understanding cell cycle arrest for its vital role in clinical therapies. The cell-cycle-arrest outcomes upon stimulation are complicated. The response could be stringent or relaxed, and graded or quantized. A model fully addressing various cell-cycle-arrest outcomes is to be developed. Here, we developed a mathematical model of cell cycle control incorporating distinct characteristics of various cell-cycle-arrest outcomes. The model can simulate two typical properties of cell cycle arrest, quantized and graded. We also characterized the inheritable quiescence and refractory state, which were crucial in long-term response of the population. Then, we monitored cells respond to multiple stimulations, and the results indicated that cells responded to stimulations with small interval did not induce significantly sustained cell cycle arrest as the existence of refractory state. Our work will benefit fundamental research and make efforts to predicting outcomes of clinical therapeutics.