Experimental febrile seizures induce age-dependent structural plasticity and improve memory in mice

Highlights • Early-stage febrile seizures improved dentate granule cell-mediated memory. • Increased mossy fiber synapses after febrile seizures underlay memory enhancement. • Late-stage febrile seizures attenuated memory enhancement via granule cell ectopia. • Abolishment of the ectopic granule cel...

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Published inNeuroscience Vol. 318; pp. 34 - 44
Main Authors Tao, K, Ichikawa, J, Matsuki, N, Ikegaya, Y, Koyama, R
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 24.03.2016
Subjects
Aging
Animals
Bumetanide - metabolism
dentate gyrus
Disease Models, Animal
febrile seizure
Fever - complications
hippocampus
Hippocampus - metabolism
Hippocampus - physiopathology
memory
Memory - physiology
Mice
Neurogenesis - physiology
Neurology
Neuronal Plasticity - physiology
Seizures - etiology
Seizures - metabolism
Seizures - physiopathology
structural plasticity
DG
LMTs
memory
phosphate buffer
DGCs
HT
Trk
FS
minimal essential medium
analyses of variance
ANOVA
ZnT3
brain-derived neurotrophic factor
protein kinase A
dentate granule cells
4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid
hyperthermia
hippocampus
BDNF
PKA
large mossy fiber terminals
Hanks’ balanced salt solution
tropomyosin receptor kinase
structural plasticity
dentate gyrus
PB
MEM
HEPES
HBSS
febrile seizure
zinc transporter 3
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Summary:Highlights • Early-stage febrile seizures improved dentate granule cell-mediated memory. • Increased mossy fiber synapses after febrile seizures underlay memory enhancement. • Late-stage febrile seizures attenuated memory enhancement via granule cell ectopia. • Abolishment of the ectopic granule cells rescued memory enhancement.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2016.01.011