Gating of hippocampal output by β-adrenergic receptor activation in the pilocarpine model of epilepsy

• Published in: Neuroscience Vol. 286; pp. 325 - 337
• Main Authors: Grosser, S, Hollnagel, J.-O, Gilling, K.E, Bartsch, J.C, Heinemann, U, Behr, J
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 12.02.2015
• Subjects: Action Potentials - drug effects; Adrenergic beta-Agonists - pharmacology; Animals; Disease Models, Animal; Electric Stimulation; Epilepsy, Temporal Lobe - chemically induced; Epilepsy, Temporal Lobe - physiopathology; Hippocampus - drug effects; Hippocampus - physiopathology; isoproterenol; Isoproterenol - pharmacology; Long-Term Potentiation; Male; multi-electrode array; Neurology; Parahippocampal Gyrus - drug effects; Parahippocampal Gyrus - physiopathology; Pilocarpine; Pyramidal Cells - drug effects; Pyramidal Cells - physiopathology; Rats; Rats, Wistar; Receptors, Adrenergic, beta - physiology; seizures; subiculum; temporal lobe epilepsy; RS; β-AR; input—output; burst-spiking cells; entorhinal cortex; LTP; isoproterenol; cAMP; TLE; BS; fEPSP; regular-spiking cells; seizures; EPSC; excitatory postsynaptic current; EC; temporal lobe epilepsy; ISO; IO; MEA; subiculum; ACSF; artificial cerebrospinal fluid; multi-electrode array; β-adrenergic receptor; field excitatory postsynaptic potential; Cyclic adenosine monophosphate; long-term potentiation
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.11.055

Highlights • Isoproterenol-induced LTP at CA1-subiculum synapses is restricted to bursting pyramidal cells. • β-AR-mediated LTP is stronger in the distal than in the proximal subiculum. • In pilocarpine-treated rats, β-AR-mediated subicular LTP is reduced at the network level but not at the cellular level. • β-AR-dependent modulation of hippocampal output is target-specifically disturbed in the pilocarpine model of epilepsy.