Discontinuous transcription

Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to ma...

Full description

Saved in:
Bibliographic Details
Published inNucleus (Austin, Tex.) Vol. 9; no. 1; pp. 149 - 160
Main Authors Smirnov, Evgeny, Hornáček, Matúš, Vacík, Tomáš, Cmarko, Dušan, Raška, Ivan
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2018
Subjects
bursting
discontinuous gene expression
kinetics
Pulsing transcription
Review
transcriptional fluctuation
discontinuous gene expression
kinetics
bursting
Pulsing transcription
transcriptional fluctuation
Online AccessGet full text

Cover

More Information
Summary:Numerous studies based on new single-cell and single-gene techniques show that individual genes can be transcribed in short bursts or pulses accompanied by changes in pulsing frequencies. Since so many examples of such discontinuous or fluctuating transcription have been found from prokaryotes to mammals, it now seems to be a common mode of gene expression. In this review we discuss the occurrence of the transcriptional fluctuations, the techniques used for their detection, their putative causes, kinetic characteristics, and probable physiological significance.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1949-1034
1949-1042
DOI:10.1080/19491034.2017.1419112