Successful treatment of rhinoorbital mucormycosis due to Rhizopus arrhizus with liposomal amphotericin B, posaconazole and surgical debridement in a child with neuroblastoma

Mucormycosis is a rare but potentially mortal opportunistic infection caused by Mucorales. We present a case of rhinoorbital mucormycosis in an 11-year old male with neuroblastoma successfully treated with aggressive surgical debridement and antifungal combination of liposomal amphotericin B and pos...

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Published inMedical mycology case reports Vol. 25; pp. 10 - 14
Main Authors Athanasiadou, Kleoniki I, Athanasiadis, Dimitrios I, Constantinidis, John, Anastasiou, Athanasia, Roilides, Emmanuel, Papakonstantinou, Evgenia
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier 01.09.2019
Subjects
Case Report
Pediatric oncology
Mucormycosis
Mucorales
Paranasal sinuses
Zygomycosis
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Summary:Mucormycosis is a rare but potentially mortal opportunistic infection caused by Mucorales. We present a case of rhinoorbital mucormycosis in an 11-year old male with neuroblastoma successfully treated with aggressive surgical debridement and antifungal combination of liposomal amphotericin B and posaconazole. Our patient developed signs of paranasal sinus infection and culture of fine needle biopsy grew . Prompt treatment and drastic surgical resection led to complete clinical and radiological recovery without evidence of mucormycosis relapse.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
These authors contributed equally to this study.
ISSN:2211-7539
2211-7539
DOI:10.1016/j.mmcr.2019.06.003