A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity

Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or v...

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Published inNature communications Vol. 11; no. 1; p. 4704
Main Authors Huang, Angkana T, Garcia-Carreras, Bernardo, Hitchings, Matt D T, Yang, Bingyi, Katzelnick, Leah C, Rattigan, Susan M, Borgert, Brooke A, Moreno, Carlos A, Solomon, Benjamin D, Trimmer-Smith, Luke, Etienne, Veronique, Rodriguez-Barraquer, Isabel, Lessler, Justin, Salje, Henrik, Burke, Donald S, Wesolowski, Amy, Cummings, Derek A T
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group UK 17.09.2020
Nature Portfolio
Subjects
Antibodies, Viral - immunology
Betacoronavirus - immunology
Coronavirus Infections - immunology
Coronavirus Infections - therapy
COVID-19
Cross Reactions
Databases, Factual
Humans
Immunization, Passive
Immunoglobulin Isotypes - immunology
Middle East Respiratory Syndrome Coronavirus - immunology
Pandemics
Pneumonia, Viral - immunology
Pneumonia, Viral - therapy
SARS-CoV-2
Seroepidemiologic Studies
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Summary:Many public health responses and modeled scenarios for COVID-19 outbreaks caused by SARS-CoV-2 assume that infection results in an immune response that protects individuals from future infections or illness for some amount of time. The presence or absence of protective immunity due to infection or vaccination (when available) will affect future transmission and illness severity. Here, we review the scientific literature on antibody immunity to coronaviruses, including SARS-CoV-2 as well as the related SARS-CoV, MERS-CoV and endemic human coronaviruses (HCoVs). We reviewed 2,452 abstracts and identified 491 manuscripts relevant to 5 areas of focus: 1) antibody kinetics, 2) correlates of protection, 3) immunopathogenesis, 4) antigenic diversity and cross-reactivity, and 5) population seroprevalence. While further studies of SARS-CoV-2 are necessary to determine immune responses, evidence from other coronaviruses can provide clues and guide future research.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-020-18450-4