DIAGNOSIS AND MANAGEMENT OF PAGET'S DISEASE OF BONE - SERIES OF 8 CASES

• Published in: Acta ortopedica brasileira Vol. 27; no. 1; pp. 31 - 32
• Main Authors: de Oliveira, Felipe Augusto Kazan, Pinto, Fábio Fernando Eloi, Sardenberg, Trajano, Pereira, Gilberto José Cação, Curcelli, Emílio Carlos, Penna, Valter
• Format: Journal Article
• Language: English
• Published: Brazil ATHA EDITORA 01.01.2019; Sociedade Brasileira de Ortopedia e Traumatologia
• Subjects: Neoplasm Metastasis; Original; ORTHOPEDICS; Osteitis Deformans; Paget´s Disease; Osteitis Deformans; Paget´s Disease; Neoplasm Metastasis; Doença de Paget; Osteíte Deformante; Metástase Neoplásica
• ISSN: 1413-7852; 1809-4406; 1809-4406
• DOI: 10.1590/1413-785220192701161107

Paget's disease of bone is a chronic condition characterized by focal abnormalities of absorption and formation of bone, and it may lead to anatomical deformities, pain, fractures, and malignant transformation. It is common in the UK, Australia, New Zealand, and North America and has a strong hereditary component, affecting first- to third-degree relatives. The etiology remains unclear and treatment is based on control of the disease with bisphosphonates, with the aim of relieving symptoms and correcting laboratory abnormalities. Surgical treatment may also be necessary to correct deformities or treat pathological fractures. This study evaluated the management and course of 8 patients with Paget's disease of bone, followed in the Orthopedic Clinic of this hospital. Among these patients, 1 had concomitant advanced prostate carcinoma, highlighting the association between Paget's disease and secondary bone diseases that can affect the differential diagnosis.