An Inside View: VEGF Receptor Trafficking and Signaling

• Published in: Physiology (Bethesda, Md.) Vol. 27; no. 4; pp. 213 - 222
• Main Author: Simons, Michael
• Format: Journal Article
• Language: English
• Published: United States 01.08.2012
• Subjects: Animals; Endocytosis; Protein Transport; Receptors, Vascular Endothelial Growth Factor - metabolism; Signal Transduction; Vascular Endothelial Growth Factor A - metabolism

Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its functio...