An Inside View: VEGF Receptor Trafficking and Signaling

Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its functio...

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Bibliographic Details
Published inPhysiology (Bethesda, Md.) Vol. 27; no. 4; pp. 213 - 222
Main Author Simons, Michael
Format Journal Article
LanguageEnglish
Published United States 01.08.2012
Subjects
Animals
Endocytosis
Protein Transport
Receptors, Vascular Endothelial Growth Factor - metabolism
Signal Transduction
Vascular Endothelial Growth Factor A - metabolism
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Summary:Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function.
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ISSN:1548-9213
1548-9221
1548-9221
DOI:10.1152/physiol.00016.2012