An Inside View: VEGF Receptor Trafficking and Signaling
Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its functio...
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| Published in | Physiology (Bethesda, Md.) Vol. 27; no. 4; pp. 213 - 222 |
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| Main Author | |
| Format | Journal Article |
| Language | English |
| Published |
United States
01.08.2012
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| Subjects | |
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| Abstract | Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function. |
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| AbstractList | Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function. Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function.Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related processes in the adult organism. Given the critical role of this signaling cascade, intricate control systems have evolved to regulate its function. A new layer of added complexity has been the demonstration of the importance of endocytosis and intracellular trafficking of VEGF receptors in the regulation of VEGF signaling. In this review, we consider an evolving link between VEGF receptor endocytosis, trafficking, and signaling and their biological function. |
| Author | Simons, Michael |
| Author_xml | – sequence: 1 givenname: Michael surname: Simons fullname: Simons, Michael organization: Departments of Internal Medicine and Cell Biology, Section of Cardiovascular Medicine, Yale Cardiovascular Research Center, New Haven, Connecticut |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22875452$$D View this record in MEDLINE/PubMed |
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| Snippet | Vascular endothelial growth factors (VEGF) and their receptors play a central role in the development of cardiovascular system and in vasculature-related... |
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| SubjectTerms | Animals Endocytosis Protein Transport Receptors, Vascular Endothelial Growth Factor - metabolism Signal Transduction Vascular Endothelial Growth Factor A - metabolism |
| Title | An Inside View: VEGF Receptor Trafficking and Signaling |
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