A case of basophilic leukemia bearing simultaneous translocations t(8;21) and t(9;22)

• Published in: Cancer genetics and cytogenetics Vol. 51; no. 2; pp. 215 - 221
• Main Authors: Xue, Yongquan, Guo, Yu, Lu, Daru, Gu, Jian, Lu, Dingwei, Gong, Jingxia, Wang, Minghua, Zhu, Wayin, Lin, Baojue
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.1991; Elsevier Science
• Subjects: Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; chromosome 8; chromosome 9; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 22; Chromosomes, Human, Pair 8; Chromosomes, Human, Pair 9; Cyclophosphamide - therapeutic use; Cytarabine - therapeutic use; Drug Combinations; Hematologic and hematopoietic diseases; Humans; Karyotyping; Leukemia, Basophilic, Acute - diagnosis; Leukemia, Basophilic, Acute - drug therapy; Leukemia, Basophilic, Acute - genetics; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; leukocytes (basophilic); Male; Medical sciences; Middle Aged; Philadelphia Chromosome; Prednisone - therapeutic use; translocation; Translocation, Genetic; Vincristine - therapeutic use; Chromosomal aberration; Cytogenetics; Abnormal chromosome; Hemopathy; Basophilic leukemia; Chromosome translocation
• ISSN: 0165-4608; 1873-4456
• DOI: 10.1016/0165-4608(91)90134-G

We report a case of basophilic leukemia with simultaneous translocations of t(8;21) and t(9;22). The patient's clinical and hematologic findings were characteristic only of t(9;22) but not of t(8;21). This unusual cytogenetic phenomenon raises a challenge to the current concepts of primary chromosomal abnormalities in cancer.