Cholecystokinin octapeptide induces endogenous opioid-dependent anxiolytic effects in morphine-withdrawal rats

• Published in: Neuroscience Vol. 277; pp. 14 - 25
• Main Authors: Wen, D, Sun, D, Zang, G, Hao, L, Liu, X, Yu, F, Ma, C, Cong, B
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 26.09.2014
• Subjects: Animals; Anti-Anxiety Agents - pharmacology; anxiety; Anxiety - drug therapy; Anxiety - physiopathology; Benzodiazepinones - pharmacology; CCK receptor; Central Nervous System Agents - pharmacology; cholecystokinin octapeptide; Devazepide - pharmacology; Dose-Response Relationship, Drug; elevated plus-maze; Male; Morphine - adverse effects; Morphine - pharmacology; Morphine Dependence - drug therapy; Morphine Dependence - physiopathology; Morphine Dependence - psychology; morphine withdrawal; Narcotics - adverse effects; Narcotics - pharmacology; Neurology; Opioid Peptides - metabolism; Phenylurea Compounds - pharmacology; Random Allocation; Rats, Wistar; Receptors, Cholecystokinin - antagonists & inhibitors; Receptors, Cholecystokinin - metabolism; Receptors, Opioid, mu - antagonists & inhibitors; Receptors, Opioid, mu - metabolism; Sincalide - pharmacology; Substance Withdrawal Syndrome - drug therapy; Substance Withdrawal Syndrome - physiopathology; Substance Withdrawal Syndrome - psychology; elevated plus-maze; anxiety; EPM; analysis of variance; ANOVA; DMSO; dimethylsulfoxide; cholecystokinin octapeptide; morphine withdrawal; CCK-8; CCK receptor
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.06.048

Highlights • CCK-8 attenuated anxiety profile in morphine-withdrawal rats. • The ‘anxiolytic’ effect of CCK-8 is mediated by the CCK1 receptor. • Mu-opioid receptor antagonism decreased the effect of CCK-8.