Harmaline-induced amnesia: Possible role of the amygdala dopaminergic system

Highlights • Pre-train infusion of SCH23390, SKF38393 and harmaline impaired memory acquisition. • Intra-BLA injection of sulpiride and quinpirole did not change memory acquisition. • Administration of SCH23390 did not alter amnesia induced by harmaline. • Infusion of SKF38393, sulpiride or quinpiro...

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Bibliographic Details
Published inNeuroscience Vol. 312; pp. 1 - 9
Main Authors Nasehi, M, Meskarian, M, Khakpai, F, Zarrindast, M.-R
Format Journal Article
LanguageEnglish
Published United States Elsevier Ltd 15.01.2016
Subjects
Amnesia - chemically induced
Animals
Basolateral Nuclear Complex - drug effects
Behavior, Animal - drug effects
BLA
Disease Models, Animal
dopamine
Dopamine Agonists - administration & dosage
Dopamine Agonists - pharmacology
Dopamine Antagonists - administration & dosage
Dopamine Antagonists - pharmacology
harmaline
Harmaline - administration & dosage
Harmaline - pharmacology
Male
memory
Mice
Monoamine Oxidase Inhibitors - administration & dosage
Monoamine Oxidase Inhibitors - pharmacology
Neurology
step-down
step-down
memory
i.p
monoamine oxidase A
harmaline
intra-BLA
analysis of variance
MAO-A
ANOVA
intra-peritoneal
intra-basolateral amygdala
BLA
dopamine
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Summary:Highlights • Pre-train infusion of SCH23390, SKF38393 and harmaline impaired memory acquisition. • Intra-BLA injection of sulpiride and quinpirole did not change memory acquisition. • Administration of SCH23390 did not alter amnesia induced by harmaline. • Infusion of SKF38393, sulpiride or quinpirole reversed amnesia caused by harmaline. • The dopaminergic system of amygdala may modulate harmaline-induced amnesia.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.11.004