Pelvic organ prolapse and collagen-associated disorders

• Published in: International Urogynecology Journal Vol. 23; no. 3; pp. 313 - 319
• Main Authors: Lammers, Karin, Lince, Sabrina L., Spath, Marian A., van Kempen, Léon C. L. T., Hendriks, Jan C. M., Vierhout, Mark E., Kluivers, Kirsten B.
• Format: Journal Article
• Language: English
• Published: London Springer-Verlag 01.03.2012; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Case-Control Studies; Cohort Studies; Collagen Diseases - epidemiology; Comorbidity; Female; Gynecology; Humans; Joint Instability - epidemiology; Medicine; Medicine & Public Health; Middle Aged; Netherlands - epidemiology; Original; Original Article; Pelvic Organ Prolapse - epidemiology; Prevalence; Urology; Varicose Veins - epidemiology; Netherlands; Rectal prolapse; Pelvic organ prolapse; Heredity; Joint hypermobility; Collagen; Varicose veins
• ISSN: 0937-3462; 1433-3023
• DOI: 10.1007/s00192-011-1532-y

Introduction and hypothesis Pelvic organ prolapse (POP) and other disorders, such as varicose veins and joint hypermobility, have been associated with changes in collagen strength and metabolism. We hypothesized that these various disorders were more prevalent in both POP patients and their family members. Methods In this study, the prevalence of various collagen-associated disorders, including POP, was compared between POP patients ( n  = 110) and control patients ( n  = 100) and their first and second degree family members. Results POP patients reported a higher prevalence of varicose veins, joint hypermobility and rectal prolapse and were more likely to have family members with POP as compared to the control group ( p  < 0.01). In contrast, the family members of the POP group did not report a higher prevalence of collagen-associated disorders compared to the family members of the control group ( p  = 0.82). Conclusions POP and other collagen-associated disorders may have a common aetiology, originating at the molecular level of the collagens.