Modes of invasion during tumour dissemination

Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope with challenging environments. This ability to switc...

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Published inMolecular oncology Vol. 11; no. 1; pp. 5 - 27
Main Authors Pandya, Pahini, Orgaz, Jose L., Sanz‐Moreno, Victoria
Format Journal Article
LanguageEnglish
Published United States John Wiley & Sons, Inc 01.01.2017
John Wiley and Sons Inc
Subjects
Actomyosin - metabolism
actomyosin contractility
Animals
Botulinum toxin
Cancer
cancer metastasis
Cell adhesion & migration
Cell division
Cell migration
Cell Movement
Epithelial-Mesenchymal Transition
Extracellular matrix
Humans
invasion
Kinases
Metastases
Metastasis
Neoplasm Invasiveness - pathology
Neoplasms - metabolism
Neoplasms - pathology
Phosphatase
Plasticity
Polymerization
Proteins
Regulation
Review
rho GTP-Binding Proteins - metabolism
Rho GTPases
Signal Transduction
Tumors
plasticity
Rho GTPases
invasion
actomyosin contractility
cancer metastasis
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Summary:Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope with challenging environments. This ability to switch migratory modes or plasticity highlights the challenges behind antimetastasis therapy design. In this Review, we present current knowledge on different tumour invasion strategies, the determinants controlling plasticity and arising therapeutic opportunities. We propose that targeting master regulators controlling plasticity is needed to hinder tumour dissemination and metastasis. This Review gives an overview of cell migration mechanisms and describes the different individual and collective modes of invasion, the plasticity that enables cancer cells to switch between modes, and the determinants of this plasticity. Therapeutic challenges arising from migratory plasticity and the potential targets that could block completely cancer cell invasion are also discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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Equal contribution
ISSN:1574-7891
1878-0261
DOI:10.1002/1878-0261.12019