Magnetic Nanoparticles in Cancer Therapy and Diagnosis

There is urgency for the development of nanomaterials that can meet emerging biomedical needs. Magnetic nanoparticles (MNPs) offer high magnetic moments and surface-area-to-volume ratios that make them attractive for hyperthermia therapy of cancer and targeted drug delivery. Additionally, they can f...

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Bibliographic Details
Published inAdvanced healthcare materials Vol. 9; no. 9; p. e1901058
Main Authors Farzin, Ali, Etesami, Seyed Alireza, Quint, Jacob, Memic, Adnan, Tamayol, Ali
Format Journal Article
LanguageEnglish
Published Germany 01.05.2020
Subjects
Contrast Media
Drug Delivery Systems
Humans
Magnetic Resonance Imaging
Magnetics
Magnetite Nanoparticles - therapeutic use
Neoplasms - diagnostic imaging
Neoplasms - therapy
cancer therapy
cancer detection
hyperthermia
drug delivery
magnetic nanoparticles
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Summary:There is urgency for the development of nanomaterials that can meet emerging biomedical needs. Magnetic nanoparticles (MNPs) offer high magnetic moments and surface-area-to-volume ratios that make them attractive for hyperthermia therapy of cancer and targeted drug delivery. Additionally, they can function as contrast agents for magnetic resonance imaging (MRI) and can improve the sensitivity of biosensors and diagnostic tools. Recent advancements in nanotechnology have resulted in the realization of the next generation of MNPs suitable for these and other biomedical applications. This review discusses methods utilized for the fabrication and engineering of MNPs. Recent progress in the use of MNPs for hyperthermia therapy, controlling drug release, MRI, and biosensing is also critically reviewed. Finally, challenges in the field and potential opportunities for the use of MNPs toward improving their properties are discussed.
ISSN:2192-2659
DOI:10.1002/adhm.201901058