Leptin and the metabolic syndrome in patients with myotonic dystrophy type 1

• Published in: Acta neurologica Scandinavica Vol. 121; no. 2; pp. 94 - 98
• Main Authors: Rakocevic Stojanovic, V., Peric, S., Lavrnic, D., Popovic, S., Ille, T., Stevic, Z., Basta, I., Apostolski, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2010; Blackwell
• Subjects: Adult; Biological and medical sciences; Blood Glucose; Blood Pressure; Body Mass Index; Cholesterol - blood; Fasting; Female; Glucose Tolerance Test; Humans; Insulin - blood; Insulin Resistance; leptin; Leptin - blood; Male; Malformations of the nervous system; Medical sciences; metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - complications; Middle Aged; Myotonic Dystrophy - blood; Myotonic Dystrophy - complications; myotonic dystrophy type 1; Neurology; Sex Characteristics; Triglycerides - blood; Endocrinopathy; Human; Neuromuscular diseases; Nervous system diseases; Myotonic dystrophy; Myotonia; Leptin; myotonic dystrophy type 1; Metabolic diseases; Cardiovascular disease; Metabolic syndrome; Genetic disease
• ISSN: 0001-6314; 1600-0404
• DOI: 10.1111/j.1600-0404.2009.01237.x

Rakocevic Stojanovic V, Peric S, Lavrnic D, Popovic S, Ille T, Stevic Z, Basta I, Apostolski S. Leptin and the metabolic syndrome in patients with myotonic dystrophy type 1.
Acta Neurol Scand: 2010: 121: 94–98.
© 2009 The Authors Journal compilation © 2009 Blackwell Munksgaard. Objectives –  To evaluate serum leptin concentration and its relation to metabolic syndrome (MSy) in non‐diabetic patients with myotonic dystrophy type 1 (DM1). Materials and methods –  This study included 34 DM1 patients, and the same number of healthy subjects matched for age, sex and body mass index (BMI). Results –  DM1 patients had increased BMI and insulin resistance, and increased leptin and insulin concentrations, but the other features of MSy such as diabetes, glucose intolerance and hypertension were not detected in DM1 patients. Serum leptin levels were higher in patients with DM1 than in healthy controls (8.5 ± 6.6 ng/ml vs 3.6 ±  2.9 ng/ml in men, and 13.9 ± 10.0 ng/ml vs 10.9 ± 6.9 ng/ml in women, respectively). In DM1 patients, leptin levels correlated with BMI, fasting insulin and insulin resistance (HOMA) (P < 0.01). Conclusions –  The leptin overproduction correlated with insulin resistance in DM1 patients but the significance of this finding remains unclear.