Weight loss decreases follicle stimulating hormone in overweight postmenopausal women
Objectives To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause. Methods Participants were postmenopausal, overweight, glucose‐intolerant women not using exogenous estrogen (n = 382) in the Diabetes Prevention Program. Women were randomi...
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| Published in | Obesity (Silver Spring, Md.) Vol. 23; no. 1; pp. 228 - 233 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Silver Spring
Blackwell Publishing Ltd
01.01.2015
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Objectives
To examine the impact of a weight loss intervention upon follicle stimulating hormone (FSH) levels in postmenopause.
Methods
Participants were postmenopausal, overweight, glucose‐intolerant women not using exogenous estrogen (n = 382) in the Diabetes Prevention Program. Women were randomized to intensive lifestyle change (ILS) with the goals of weight reduction of at least 7% of initial weight and 150 min per week of moderate‐intensity exercise, metformin 850 mg twice a day, or placebo administered twice a day.
Results
Randomization to ILS led to small increases in FSH between baseline and 1‐year follow‐up vs. placebo (2.3 IU/l vs. −0.81 IU/l, P < 0.01). Increases in FSH were correlated with decreases in weight (r = −0.165, P < 0.01) and estradiol (E2) (r = −0.464, P < 0.0001) after adjustment for age, race/ethnicity, and randomization arm. Changes in FSH were still significantly associated with changes in weight even after adjustment for E2 levels. Metformin users had reductions in weight but non‐significant changes in FSH and E2 levels vs. placebo.
Conclusions
Weight loss leads to small increases in FSH among overweight, postmenopausal women, potentially through pathways mediated by endogenous estrogen as well as other pathways. |
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| Bibliography: | Disclosure Author Contribution Funding agencies None of the authors have a conflict of interest. CK conceived the research question, drafted the manuscript, and oversaw the statistical analysis and design; SK performed the statistical analysis; EBC reviewed manuscript drafts; BN reviewed the statistical analysis; JFR reviewed manuscript drafts, FL conducted the assays and reviewed manuscript drafts. All authors had final approval of the submitted and published versions. The project described was supported by Award Numbers U01DK048489, R01DK083297, and K23DK071552 from The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). The NIDDK provided funding to the clinical centers and the Coordinating Center for the design and conduct of the study and for collection, management, analysis, and interpretation of the Diabetes Prevention Program. The Southwestern American Indian Centers were supported directly by the NIDDK and the Indian Health Service. The General Clinical Research Center Program, National Center for Research Resources supported data collection at many of the clinical centers. Funding for data collection and participant support was also provided by the National Institute of Child Health and Human Development, the National Institute on Aging, the Office of Research on Women's Health, the Office of Research on Minority Health, the Centers for Disease Control and Prevention, and the American Diabetes Association. This research was also supported, in part, by the intramural research program of the NIDDK. McKesson BioServices Corp., Matthews Media Group, Inc., and the Henry M. Jackson Foundation provided support services under subcontract with the Coordinating Center. |
| ISSN: | 1930-7381 1930-739X |
| DOI: | 10.1002/oby.20917 |