Variation in outcome reporting in studies of fertility‐sparing surgery for cervical cancer: A systematic review

Background Cervical cancer affects 3197 women in the UK, and 604 000 women worldwide annually, with peak incidence seen in women between 30 and 34 years of age. For many, fertility‐sparing surgery is an appealing option where possible. However, absence of large‐scale data, along with a notable varia...

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Published inBJOG : an international journal of obstetrics and gynaecology Vol. 130; no. 2; pp. 163 - 175
Main Authors Yong, Nathanael, Cooper, Natalie, Yorke, Sarah, Baran, Chawan, Khan, Khalid, Tan, Alex, Sideris, Michail, Iliodromiti, Stamatina, Manchanda, Ranjit
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.01.2023
John Wiley and Sons Inc
Subjects
Cervical cancer
Cervix
Clinical trials
Complications
core outcomes
Data collection
Female
Fertility
fertility‐sparing
Humans
Postoperative
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Pregnancy
Pregnancy complications
Quality of Life
Surgery
Systematic Review
Systematic Reviews
Treatment Outcome
Uterine Cervical Neoplasms - surgery
Variation
Womens health
core outcomes
fertility-sparing
cervical cancer
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Summary:Background Cervical cancer affects 3197 women in the UK, and 604 000 women worldwide annually, with peak incidence seen in women between 30 and 34 years of age. For many, fertility‐sparing surgery is an appealing option where possible. However, absence of large‐scale data, along with a notable variation in reported outcomes in relevant studies, may undermine future efforts for consistent evidence synthesis. Objectives To systematically review the reported outcomes measured in studies that include women who underwent fertility‐sparing surgery for cervical cancer and identify whether variation exists. Search strategy We searched MEDLINE, EMBASE and CENTRAL from inception to February 2019. Selection criteria Randomised controlled trials, cohort and observational studies, and case studies of more than ten participants from January 1990 to date. Data collection and analysis Study characteristics and all reported treatment outcomes. Main results A total of 104 studies with a sum of 9535 participants were identified. Most studies reported on oncological outcomes (97/104), followed by fertility and pregnancy (86/104), postoperative complications (74/104), intra‐operative complications (72/104) and quality of life (5/104). There was huge variation and heterogeneity in reported outcomes, with only 12% being good quality and 87% being of poor quality. Conclusions There is significant heterogeneity in the reported outcomes. An agreed Core Outcome Set is necessary for future studies to effectively harmonise reported outcomes that are measurable and relevant to patients, clinicians and researchers. This systematic review sets the groundwork for the development of a Core Outcome Set for fertility‐sparing surgery in cervical cancer. This article includes Author Insights, a video available at: https://vimeo.com/771508530
Bibliography:Natalie Cooper, Michail Sideris, Stamatina Iliodromiti and Ranjit Manchanda contributed equally to this study.
https://vimeo.com/771508530
This article includes Author Insights, a video abstract available at
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This article includes Author Insights, a video abstract available at: https://vimeo.com/771508530
ISSN:1470-0328
1471-0528
DOI:10.1111/1471-0528.17342