Pro-urokinase promotes angiogenesis but does not reduce neuronal apoptosis in infarcted cerebral tissue
Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is wid...
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Published in | Neural regeneration research Vol. 9; no. 5; pp. 502 - 503 |
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Language | English |
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Medknow Publications and Media Pvt. Ltd
01.03.2014
Medknow Publications & Media Pvt. Ltd Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical Uni-versity, Beijing, China%Department of Neurology, Affiliated Tangshan Workers’ Hospital of Hebei Medical University, Tangshan, Hebei Province, China%Department of Neurology, People’s Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China Medknow Publications & Media Pvt Ltd |
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Abstract | Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally (Albers et al., 2008). In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use. |
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AbstractList | Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally (Albers et al., 2008). In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use. A previous study found that the recanalization rate was significantly higher after arterial thrombolysis with pro-urokinase than with recombinant tissue plasminogen activator (Fischer et al., 2005). The results of this study show that recanalization after thromboembolism was similar after thrombolysis with pro-urokinase and recombinant tissue plasminogen activator, and that both these drugs were more effective than urokinase (both P < 0.05). [...]pro-urokinase and recombinant tissue plasminogen activator did not have any definite protective effects against neuronal injury. |
Audience | Academic |
Author | Wei Qin Lei Yang Hongmei Guo Ning Xiang Wenli Hu |
AuthorAffiliation | Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical Uni- versity, Beijing, China Department of Neurology, Affiliated Tangshan Workers' Hospital of Hebei Medical University, Tangshan, Hebei Province, China Department of Neurology, People's Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China |
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Notes | Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally (Albers et al., 2008). In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use. 11-5422/R ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Author contributions: Qin W wrote this paper. All authors participated in experimental design, performance and evaluation and approved the final version of this paper. |
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References | 18574275 - Chest. 2008 Jun;133(6 Suppl):630S-669S 15580491 - Neuroradiology. 2004 Dec;46(12 ):988-95 8797424 - Chest. 1996 Sep;110(3):762-6 17968964 - J Magn Reson Imaging. 2007 Dec;26(6):1421-8 16224085 - Stroke. 2005 Nov;36(11):2415-20 16151026 - Stroke. 2005 Oct;36(10):2121-5 9566365 - Neurology. 1998 Apr;50(4):870-5 |
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SubjectTerms | Apoptosis Bats Blood clots Carotid arteries Comparative analysis Complications and side effects Dogs Dosage and administration Drug therapy Embolisms Embolization Imaging in Neural Regeneration Medical imaging Physiological aspects Physiology Stroke Stroke (Disease) Tissue plasminogen activator Urokinase Veins & arteries 尿激酶原 核苷酸酶 溶栓药物 神经细胞凋亡 组织型纤溶酶原激活剂 脑组织 血栓形成 血管生成 |
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Title | Pro-urokinase promotes angiogenesis but does not reduce neuronal apoptosis in infarcted cerebral tissue |
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