Pro-urokinase promotes angiogenesis but does not reduce neuronal apoptosis in infarcted cerebral tissue

Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is wid...

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Published inNeural regeneration research Vol. 9; no. 5; pp. 502 - 503
Main Authors Qin, Wei, Yang, Lei, Guo, Hongmei, Xiang, Ning, Hu, Wenli
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.03.2014
Medknow Publications & Media Pvt. Ltd
Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical Uni-versity, Beijing, China%Department of Neurology, Affiliated Tangshan Workers’ Hospital of Hebei Medical University, Tangshan, Hebei Province, China%Department of Neurology, People’s Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China
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Abstract Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally (Albers et al., 2008). In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use.
AbstractList Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally (Albers et al., 2008). In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use.
A previous study found that the recanalization rate was significantly higher after arterial thrombolysis with pro-urokinase than with recombinant tissue plasminogen activator (Fischer et al., 2005). The results of this study show that recanalization after thromboembolism was similar after thrombolysis with pro-urokinase and recombinant tissue plasminogen activator, and that both these drugs were more effective than urokinase (both P < 0.05). [...]pro-urokinase and recombinant tissue plasminogen activator did not have any definite protective effects against neuronal injury.
Audience Academic
Author Wei Qin Lei Yang Hongmei Guo Ning Xiang Wenli Hu
AuthorAffiliation Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical Uni- versity, Beijing, China Department of Neurology, Affiliated Tangshan Workers' Hospital of Hebei Medical University, Tangshan, Hebei Province, China Department of Neurology, People's Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China
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Notes Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally (Albers et al., 2008). In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use.
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Author contributions: Qin W wrote this paper. All authors participated in experimental design, performance and evaluation and approved the final version of this paper.
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Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical Uni-versity, Beijing, China%Department of Neurology, Affiliated Tangshan Workers’ Hospital of Hebei Medical University, Tangshan, Hebei Province, China%Department of Neurology, People’s Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China
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Snippet Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing...
A previous study found that the recanalization rate was significantly higher after arterial thrombolysis with pro-urokinase than with recombinant tissue...
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SubjectTerms Apoptosis
Bats
Blood clots
Carotid arteries
Comparative analysis
Complications and side effects
Dogs
Dosage and administration
Drug therapy
Embolisms
Embolization
Imaging in Neural Regeneration
Medical imaging
Physiological aspects
Physiology
Stroke
Stroke (Disease)
Tissue plasminogen activator
Urokinase
Veins & arteries
尿激酶原
核苷酸酶
溶栓药物
神经细胞凋亡
组织型纤溶酶原激活剂
脑组织
血栓形成
血管生成
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Title Pro-urokinase promotes angiogenesis but does not reduce neuronal apoptosis in infarcted cerebral tissue
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