Pro-urokinase promotes angiogenesis but does not reduce neuronal apoptosis in infarcted cerebral tissue

• Published in: Neural regeneration research Vol. 9; no. 5; pp. 502 - 503
• Main Authors: Qin, Wei, Yang, Lei, Guo, Hongmei, Xiang, Ning, Hu, Wenli
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01.03.2014; Medknow Publications & Media Pvt. Ltd; Department of Neurology, Beijing Chao-Yang Hospital, Capital Medical Uni-versity, Beijing, China%Department of Neurology, Affiliated Tangshan Workers’ Hospital of Hebei Medical University, Tangshan, Hebei Province, China%Department of Neurology, People’s Hospital of Qinhuangdao, Qinhuangdao, Hebei Province, China; Medknow Publications & Media Pvt Ltd
• Subjects: Apoptosis; Bats; Blood clots; Carotid arteries; Comparative analysis; Complications and side effects; Dogs; Dosage and administration; Drug therapy; Embolisms; Embolization; Imaging in Neural Regeneration; Medical imaging; Physiological aspects; Physiology; Stroke; Stroke (Disease); Tissue plasminogen activator; Urokinase; Veins & arteries; 尿激酶原; 核苷酸酶; 溶栓药物; 神经细胞凋亡; 组织型纤溶酶原激活剂; 脑组织; 血栓形成; 血管生成; China
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.130072

Ischemic stroke is most commonly caused by vascular occlusion due to thrombosis or arterial embolism. Recently, thrombolysis has been used with increasing frequency for the treatment of acute ischemic stroke. Among the drugs used for thrombolysis, only recombinant tissue plasminogen activator is widely accepted internationally （Albers et al., 2008）. In China, urokinase has been widely used for thrombolysis after acute ischemic stroke. Pro-uro- kinase is the precursor of urokinase. Compared with urokinase, pro-uroki- nase has greater ability to dissolve thrombus and is safer to use.