Analgesic, Antioxidant, Anti-Inflammatory, and Wound-Treating Actions of Bitter Apricot Kernel Extract

• Published in: Advances in pharmacological and pharmaceutical sciences Vol. 2024; no. 1; p. 5574259
• Main Authors: El-Hajjaji, Mohamed Amine, Fikri-Benbrahim, Kawtar, Soulo, Najoua, Nouioura, Ghizlane, Laaroussi, Hassan, Ferreira-Santos, Pedro, Lyoussi, Badiaa, Benziane Ouaritini, Zineb
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 31.08.2024; Hindawi Limited; Wiley
• Subjects: Acids; Aluminum; Analgesics; Anti-inflammatory agents; Anti-inflammatory drugs; Antioxidants; Ethanol; Flowers & plants; Fruits; High performance liquid chromatography; Inflammation; Isoflavones; Medical research; Pain; Pain management; Phytochemicals; Placebo effect; Potassium; Resveratrol; Sodium; Wound healing; Morocco
• ISSN: 2633-4682; 2633-4690; 2633-4690
• DOI: 10.1155/2024/5574259

Apricot ( L.) kernels have been widely employed in phytomedicine for treating different ailments. This study aims to unveil the phytochemical composition by HPLC-ESI-MS, antioxidant activity, and examine certain pharmacological effects of the hydro-ethanolic extract from bitter apricot kernels (BAK). Obtained results indicated that the BAK extract presents a content of 4.58 ± 0.15 mg GAE/g extract of TPA and 1.68 ± 0.09 mg QUE/g extract of TFA, respectively. HPLC-ESI-MS analysis discovered the presence of 17 phenolic compounds including phenolic acids and flavonoids like 3,4-dihydroxybenzoic acid, gallic acid, caffeic acid, (+)-catechin, epicatechin, and others, with associated antioxidant power. Regarding the studied potential pharmacological effects, notable analgesic activity at a dosage of 100 mg/kg BW was recorded with 63.46% protection. In the anti-inflammatory test, significant inhibition was observed after 6 hours of treatment (77.4%) compared to untreated animals. Moreover, the daily application of ointment formulated with 10% BAK extract resulted in a remarkable healing of wounds and burns in rats. These findings underscore the increasing evidence supporting the potential use of apricot kernel extracts in treating various diseases.