Changes in EP and inner ear ionic concentrations in experimental endolymphatic hydrops

Unilateral endolymphatic hydrops was created in guinea pigs by endolymphatic duct obstruction. Using microelectrodes, studies of endocochlear potential (EP) and inner ear ionic concentrations were performed. EP was significantly decreased whereas Na+, K+, and Cl- concentrations in both scala media a...

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Bibliographic Details
Published inActa oto-laryngologica Vol. 98; no. 5-6; p. 398
Main Authors Cohen, J, Morizono, T
Format Journal Article
LanguageEnglish
Published England 01.01.1984
Subjects
Animals
Chlorides - analysis
Cochlea - analysis
Edema - metabolism
Edema - physiopathology
Endolymphatic Duct
Guinea Pigs
Ions
Labyrinth Diseases - metabolism
Labyrinth Diseases - physiopathology
Labyrinthine Fluids - analysis
Membrane Potentials
Potassium - analysis
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Summary:Unilateral endolymphatic hydrops was created in guinea pigs by endolymphatic duct obstruction. Using microelectrodes, studies of endocochlear potential (EP) and inner ear ionic concentrations were performed. EP was significantly decreased whereas Na+, K+, and Cl- concentrations in both scala media and scala tympani were not significantly altered. The presence of a decreased EP after endolymphatic duct obstruction appears to be a reliable indicator for the presence of hydrops. This decrease in EP without ionic concentration changes suggests that it is the electrogenic portion of EP which is altered in hydrops.
ISSN:0001-6489
DOI:10.3109/00016488409107580