Lack of effect of intravenous metformin on plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in non-diabetic subjects

A study was carried out to evaluate the acute effect of an intravenous injection of metformin on the fasting plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in 15 non-diabetic subjects. Metformin (1 g) was administered as a bolus in a peripheral vein and blood was s...

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Bibliographic Details
Published inCurrent medical research and opinion Vol. 9; no. 1; p. 47
Main Authors Bonora, E, Cigolini, M, Bosello, O, Zancanaro, C, Capretti, L, Zavaroni, I, Coscelli, C, Butturini, U
Format Journal Article
LanguageEnglish
Published England 1984
Subjects
Adult
Blood Glucose - metabolism
C-Peptide - blood
Female
Glucagon - blood
Growth Hormone - blood
Humans
Injections, Intravenous
Insulin - blood
Male
Metformin - administration & dosage
Metformin - pharmacology
Middle Aged
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Summary:A study was carried out to evaluate the acute effect of an intravenous injection of metformin on the fasting plasma concentrations of glucose, insulin, C-peptide, glucagon and growth hormone in 15 non-diabetic subjects. Metformin (1 g) was administered as a bolus in a peripheral vein and blood was sampled 2, 5, 10, 15 and 30 minutes after the drug injection. No significant change in fasting concentration of glucose nor in C-peptide, insulin, glucagon and growth hormone fasting levels was noticed. It is concluded that metformin does not possess an acute direct hypoglycaemic effect in non-diabetic subjects and does not acutely affect the basal activity of endocrine pancreas and pituitary gland in releasing insulin, glucagon and growth hormone.
ISSN:0300-7995
DOI:10.1185/03007998409109558