Cancer metabolism: facts, fantasy, and fiction

The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here...

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Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 313; no. 3; pp. 459 - 465
Main Authors Zu, Xin Lin, Guppy, Michael
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 16.01.2004
Subjects
Adenosine Triphosphate - chemistry
Animals
Glycolysis
Humans
Hypoxia
Neoplasms - metabolism
Oxygen - metabolism
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Summary:The concept of a glycolytic cancer cell was introduced by Warburg over 70 years ago. This perception has since become the rationale that drives a considerable proportion of basic research on cancer, and it influences the current strategies for the diagnosis, monitoring, and treatment of cancer. Here we review the data from the last 40 years on this issue. We conclude that there is no evidence that cancer cells are inherently glycolytic, but that some tumours might indeed be glycolytic in vivo as a result of their hypoxic environment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2003.11.136