Isolation and genotype analysis of rubella virus from a case of Guillain-Barré syndrome

• Published in: Journal of clinical virology Vol. 43; no. 3; pp. 343 - 345
• Main Authors: Figueiredo, C.A, Klautau, G.B, Afonso, A.M.S, Castrignano, S.B, Oliveira, M.I, Curti, S.P, Squarcina, G.G, Narimatsu, K, Rasslan, Z, Lima, C.A.C, Golin, V, Tadeo, E.F, Spagunolo, F.J, Cataldo, B, Durigon, E.L
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.11.2008; Elsevier Science
• Subjects: Adolescent; Allergy and Immunology; Biological and medical sciences; Blood - virology; Cerebrospinal fluid; Cerebrospinal Fluid - virology; Female; Fundamental and applied biological sciences. Psychology; Guillain-Barre Syndrome - virology; Guillain-Barré syndrome; Human viral diseases; Humans; Infectious Disease; Infectious diseases; Leukocytes, Mononuclear - virology; Medical sciences; Microbiology; Miscellaneous; Peripheral blood mononuclear cells; Rubella virus; Rubella virus - classification; Rubella virus - genetics; Rubella virus - isolation & purification; Viral diseases; Virology; Virus isolation; peripheral blood mononuclear cells; RT; RV; immunoglobulin; rubella virus; PBMC; Virus isolation; Guillain-Barré syndrome; reverse transcription; CSF; cerebrospinal fluid; GBS; PCR; polymerase chain reaction; Ig; Peripheral blood mononuclear cells; Cerebrospinal fluid; Rubella virus; Nervous system diseases; Microbiology; Rubivirus; Peripheral blood circulation; Togaviridae; Genotype; Inflammatory disease; Virology; Virus; Blood cell; Mononuclear cell; Isolation; Peripheral nerve disease
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2008.07.015

Abstract Rubella virus (RV) infection has sporadically been linked to Guillain-Barré syndrome (GBS), but the association with RV has been based only on clinical and/or serological backgrounds. In the present case it was possible to isolate RV (genotype 1a) from cerebrospinal fluid and peripheral blood mononuclear cells of an 18-year-old woman diagnosed with GBS after clinical manifestations of rubella. This report contributes to confirm RV as one of the triggering pathogens of this peripheral nervous system disease.