How can we identify low- and high-risk patients among unselected patients with possible acute coronary syndrome?

• Published in: The American journal of emergency medicine Vol. 25; no. 1; pp. 23 - 31
• Main Authors: Nielsen, Kirsten Melgaard, MD, PhD, Faergeman, Ole, MD, DMSc, Larsen, Mogens Lytken, MD, DMSc, Foldspang, Anders, MD, PhD, DMSc
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 2007; Elsevier; Elsevier Limited
• Subjects: Acute coronary syndromes; Adult; Aged; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Angina pectoris; Angina, Unstable - diagnosis; Biological and medical sciences; Blood. Blood coagulation. Reticuloendothelial system; Cardiology. Vascular system; Cohort Studies; Coronary Care Units; Coronary Disease - diagnosis; Coronary Disease - mortality; Coronary Disease - physiopathology; Coronary heart disease; Denmark; Electrocardiography; Emergency; Emergency medical care; Female; Health risks; Heart; Heart attacks; Humans; Intensive care medicine; Logistic Models; Male; Medical sciences; Middle Aged; Mortality; Mortality risk; Pharmacology. Drug treatments; Prognosis; Risk Factors; Statistical models; Studies; Denmark; Human; Myocardial infarction; Intensive care; Risk factor; Cardiovascular disease; Coronary heart disease; Myocardial disease; Variant angina; Resuscitation
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/j.ajem.2006.06.003

Abstract Objective Prognosis among patients admitted with possible acute coronary syndrome (ACS) may differ from that of patients with definite ACS. The aim of this study was to identify risk factors for mortality among unselected patients and to use the statistical model to identify patients at low or high mortality risk. Methods From April 1, 2000, to March 31, 2002, we identified all consecutive patients aged 30 to 69 years admitted to the 2 coronary care units covering the municipality of Aarhus, Denmark (population, 138 290). ACS was considered a possible diagnosis if the physician at admission (1) had noted the presence or absence of chest pain, (2) performed a 12-lead electrocardiogram, and (3) measured markers of myocardial necrosis. In 1576 consecutive patients these criteria were fulfilled. Results By logistic regression, predictors of mortality were age 60 and older, ST elevation, right bundle-branch block, arrhythmia, elevated markers of myocardial necrosis, and the diagnosis of ACS. The predictive validity of the model, as indicated by receiver operating characteristic curve area, was 85.7%, 87.8%, and 80.1% for 7-, 30-, and 365-day mortality, respectively. Conclusions Mortality may be predicted with high precision based on a statistical model. Identification of survivors by the use of a statistical model was superior as compared to simply ruling out the clinical diagnosis of ACS.