Two consecutive recurrences of crescentic immunoglobulin A nephropathy in a renal transplant recipient

We report a 21-year-old male who developed end-stage renal disease, probably due to immunoglobulin A nephropathy (IgAN), received a renal transplant from his mother, which was lost due to crescentic IgAN after 18 months. Two years later, he received a second transplant from a deceased donor. He deve...

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Published inIndian journal of nephrology Vol. 26; no. 5; pp. 376 - 378
Main Authors Gopalakrishnan, N, Murugananth, S, Dineshkumar, T, Dhanapriya, J, Sakthirajan, R, Balasubramaniyan, T
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer - Medknow Publications 01.09.2016
Medknow Publications and Media Pvt. Ltd
Scientific Scholar
Medknow Publications & Media Pvt Ltd
Subjects
Case Report
Case studies
Health aspects
Immunoglobulin A
Kidney transplantation
Patient outcomes
India
recurrence
Allograft biopsy
graft loss
crescentic immunoglobulin A
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Summary:We report a 21-year-old male who developed end-stage renal disease, probably due to immunoglobulin A nephropathy (IgAN), received a renal transplant from his mother, which was lost due to crescentic IgAN after 18 months. Two years later, he received a second transplant from a deceased donor. He developed rapidly progressive graft dysfunction 3 years later. Allograft biopsy revealed crescentic IgAN, which was successfully treated with intravenous steroids and cyclophosphamide. Recurrence of IgAN in two successive allografts in one patient has not been reported previously.
ISSN:0971-4065
1998-3662
DOI:10.4103/0971-4065.169565