Lipid Lowering Activity of Citri Unshii Pericarpium in Hyperlipemic Rats

The inhibitory effect of the MeOH extract of Citri unshii pericarpium (CU) and its fractions were tested in hyperlipemic rats using for animal models induced by high cholesterol-diet. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol and high-den...

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Published inImmunopharmacology and immunotoxicology Vol. 30; no. 4; pp. 783 - 791
Main Authors Yang, Gabsik, Lee, Juyeong, Jung, Eui-Dong, Ham, Inhye, Choi, Ho-Young
Format Journal Article
LanguageEnglish
Published England Informa UK Ltd 01.01.2008
Taylor & Francis
Subjects
Animals
Body Weight; Triglyceride
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Citri Unshii Pericarpium
Citrus
High-Cholesterol Diet
High-Density Lipoprotein Cholesterol
Hyperlipidemias - blood
Hyperlipidemias - drug therapy
Hypolipidemic Agents - therapeutic use
Lipids - blood
Low-Density Lipoprotein Cholesterol
Male
Plant Extracts - therapeutic use
Plant Structures
Rat; Hyperlipidemia
Rats
Rats, Sprague-Dawley
Simvastatin - therapeutic use
Triglycerides - blood
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Abstract The inhibitory effect of the MeOH extract of Citri unshii pericarpium (CU) and its fractions were tested in hyperlipemic rats using for animal models induced by high cholesterol-diet. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol as measures of its hyperlipemic effects. We demonstrated that CU decreases plasma levels of triglyceride, total cholesterol and LDL cholesterol. There was also no elevation of plasma ALT and AST levels, which indicate CU did not cause liver injury. These results indicate that CU is a good candidate for the treatment on high cholesterol diet-induced blood circulatory disorders, obesity and hyperlipidemia.
AbstractList The inhibitory effect of the MeOH extract of Citri unshii pericarpium (CU) and its fractions were tested in hyperlipemic rats using for animal models induced by high cholesterol-diet. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol as measures of its hyperlipemic effects. We demonstrated that CU decreases plasma levels of triglyceride, total cholesterol and LDL cholesterol. There was also no elevation of plasma ALT and AST levels, which indicate CU did not cause liver injury. These results indicate that CU is a good candidate for the treatment on high cholesterol diet-induced blood circulatory disorders, obesity and hyperlipidemia.
Author Choi, Ho-Young
Yang, Gabsik
Ham, Inhye
Jung, Eui-Dong
Lee, Juyeong
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Snippet The inhibitory effect of the MeOH extract of Citri unshii pericarpium (CU) and its fractions were tested in hyperlipemic rats using for animal models induced...
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SubjectTerms Animals
Body Weight; Triglyceride
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Citri Unshii Pericarpium
Citrus
High-Cholesterol Diet
High-Density Lipoprotein Cholesterol
Hyperlipidemias - blood
Hyperlipidemias - drug therapy
Hypolipidemic Agents - therapeutic use
Lipids - blood
Low-Density Lipoprotein Cholesterol
Male
Plant Extracts - therapeutic use
Plant Structures
Rat; Hyperlipidemia
Rats
Rats, Sprague-Dawley
Simvastatin - therapeutic use
Triglycerides - blood
Title Lipid Lowering Activity of Citri Unshii Pericarpium in Hyperlipemic Rats
URI https://www.tandfonline.com/doi/abs/10.1080/08923970802279167
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Volume 30
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