Lipid Lowering Activity of Citri Unshii Pericarpium in Hyperlipemic Rats

• Published in: Immunopharmacology and immunotoxicology Vol. 30; no. 4; pp. 783 - 791
• Main Authors: Yang, Gabsik, Lee, Juyeong, Jung, Eui-Dong, Ham, Inhye, Choi, Ho-Young
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2008; Taylor & Francis
• Subjects: Animals; Body Weight; Triglyceride; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Citri Unshii Pericarpium; Citrus; High-Cholesterol Diet; High-Density Lipoprotein Cholesterol; Hyperlipidemias - blood; Hyperlipidemias - drug therapy; Hypolipidemic Agents - therapeutic use; Lipids - blood; Low-Density Lipoprotein Cholesterol; Male; Plant Extracts - therapeutic use; Plant Structures; Rat; Hyperlipidemia; Rats; Rats, Sprague-Dawley; Simvastatin - therapeutic use; Triglycerides - blood
• ISSN: 0892-3973; 1532-2513
• DOI: 10.1080/08923970802279167

The inhibitory effect of the MeOH extract of Citri unshii pericarpium (CU) and its fractions were tested in hyperlipemic rats using for animal models induced by high cholesterol-diet. We measured plasma levels of triglyceride, total cholesterol, low-density lipoprotein (LDL)-cholesterol and high-density lipoprotein (HDL)-cholesterol as measures of its hyperlipemic effects. We demonstrated that CU decreases plasma levels of triglyceride, total cholesterol and LDL cholesterol. There was also no elevation of plasma ALT and AST levels, which indicate CU did not cause liver injury. These results indicate that CU is a good candidate for the treatment on high cholesterol diet-induced blood circulatory disorders, obesity and hyperlipidemia.