Complexation of Gold(III) with Pyridoxal 5′-Phosphate-Derived Hydrazones in Aqueous Solution

Today, complexes of gold(I) and gold(III) are recognized as promising drugs for the treatment of bacterial infectious diseases and oncological diseases, respectively. It is of interest to broaden the area of potential use of gold(III) compounds to the pathogenic microorganism as well. The first step...

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Published inMolecules (Basel, Switzerland) Vol. 27; no. 21; p. 7346
Main Authors Kuranova, Natalia N, Yarullin, Daniil N, Zavalishin, Maksim N, Gamov, George A
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 28.10.2022
MDPI
Subjects
Aldehydes
Antibiotics
Antiinfectives and antibacterials
Aqueous solutions
Auranofin
BCG
BCG vaccines
Bioactive compounds
Biological activity
Complex formation
Complexation
Drug development
Drug resistance in microorganisms
Fluorescence
Gold
gold(III)
hydrazone
Hydrazones
Infectious diseases
Ligands
Mass spectrometry
Mass spectroscopy
Microorganisms
Pathogens
Phosphates
Physiological aspects
pyridoxal 5′-phosphate
Speciation
Stability
stability constant
Titration
Tuberculosis
Russia
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Summary:Today, complexes of gold(I) and gold(III) are recognized as promising drugs for the treatment of bacterial infectious diseases and oncological diseases, respectively. It is of interest to broaden the area of potential use of gold(III) compounds to the pathogenic microorganism as well. The first step towards the development of new antibacterial drugs based on Au3+ complexes is the study of their stability in an aqueous solution. The present contribution reports on the investigation of gold(III) complexation with five hydrazones derived from a well-known biologically active compound, pyridoxal 5′-phosphate (one of the aldehyde forms of the B6 vitamin). The complex formation in aqueous solutions was confirmed by mass spectrometry and fluorescent spectroscopy. The stoichiometric composition of the complexes formed and their stability constants were determined using a UV–Vis titration method. The complexes are quite stable at physiological values of pH, as the speciation diagrams show. The results of the paper are helpful for further studies of gold(III) complexes interaction with biomacromolecules.
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ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27217346