Different susceptibility to polycyclic aromatic hydrocarbons (PAH)-induced DNA damage in lung tissue in male and female non-smokers

The levels of benzo(a)pyrene diol-epoxide (BPDE)-DNA adducts and polycyclic aromatic hydrocarbons (PAH) were analysed in a limited number of samples of autoptic lung tissue obtained from non-professionally exposed male (n= 13) and female (n= 12) non-smokers in an attempt to evaluate the relationship...

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Published inBiomarkers Vol. 5; no. 6; pp. 447 - 451
Main Authors LODOVICI, M, AKPAN, V, CASALINI, C, DOLARA, P
Format Journal Article
LanguageEnglish
Published London Informa UK Ltd 2000
Taylor & Francis
Subjects
Biological and medical sciences
Chemical and industrial products toxicology. Toxic occupational diseases
Medical sciences
Polycyclic Aromatic Hydrocarbons Bpde-DNA Adducts Human Lung Carcinogenesis
Toxicology
Various organic compounds
Human
Toxicity
Lung
Sex
Male
Polycyclic aromatic compound
Non smoker
Carcinogen
Pollutant
Autopsy
DNA
Environment
Female
Molecular adduct
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Summary:The levels of benzo(a)pyrene diol-epoxide (BPDE)-DNA adducts and polycyclic aromatic hydrocarbons (PAH) were analysed in a limited number of samples of autoptic lung tissue obtained from non-professionally exposed male (n= 13) and female (n= 12) non-smokers in an attempt to evaluate the relationship between gender, lung PAH levels (n= 25) and susceptibility to BPDE-DNA adduct formation (n= 18). Lung concentrations of chrysene, benzo(g,h,i)perylene and benzo(a)pyrene were significantly higher in males than in females (P
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ISSN:1354-750X
1366-5804
DOI:10.1080/135475000750052457