Local Allergic Rhinitis: Lights and Shadows of a Mysterious Entity

• Published in: International archives of allergy and immunology Vol. 184; no. 1; p. 12
• Main Authors: Melone, Giulio, Giorgis, Veronica, Di Pino, Marina, Pelaia, Corrado, Nappi, Emanuele, Heffler, Enrico, Landi, Massimo, Gelardi, Matteo, Paoletti, Giovanni
• Format: Journal Article
• Language: English
• Published: Switzerland 2023
• Subjects: Allergens; Humans; Immunoglobulin E; Nasal Provocation Tests; Prospective Studies; Rhinitis; Rhinitis, Allergic - diagnosis; Rhinitis, Allergic - therapy; Skin Tests; Nasal allergen provocation test; Local allergic rhinitis; Nasal cytology; Nonallergic rhinitis; IgE
• ISSN: 1423-0097
• DOI: 10.1159/000526604

Local allergic rhinitis (LAR) is, to date, a debated and complex entity, still orphan of global consideration and a multicentric approach. LAR does not seem to find a proper positioning in the classic classifications and phenotypes of chronic rhinitis, and its pathophysiology relies specifically on the presence of local IgE. These patients in fact have a suggestive clinical history of allergic rhinitis in the presence of negative skin prick tests and serum IgE tests for the suspect allergen. Nasal allergen challenge, assessment of local IgE, basophil activation test (BAT), and nasal cytology are, at the moment, the most used tests in the diagnostic approach to the disease, despite their limitations. Considering that the correct interpretation of diagnostic tests and their clinical relevance is fundamental in the assessment of the right diagnosis and the subsequent therapy, we propose a new diagnostic approach that encompasses all of these methodologies and suggest that several pragmatic randomized control trials as well as prospective, multicentric studies directed at the long-term follow-up of LAR be carried out to further investigate this debated entity.