Sexually dimorphic expression of a teleost homologue of Müllerian inhibiting substance during gonadal sex differentiation in Japanese flounder, Paralichthys olivaceus

Müllerian inhibiting substance (MIS), also known as anti-Müllerian hormone, is a glycoprotein belonging to transforming growth factor β superfamily. In mammals, MIS is responsible for regression of Müllerian ducts, anlagen of the female reproductive ducts, in the male fetus. However, the role of MIS...

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Published inBiochemical and biophysical research communications Vol. 322; no. 2; pp. 508 - 513
Main Authors Yoshinaga, Norifumi, Shiraishi, Eri, Yamamoto, Takashi, Iguchi, Taisen, Abe, Shin-ichi, Kitano, Takeshi
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 17.09.2004
Subjects
Amino Acid Sequence
Animals
Anti-Mullerian Hormone
Anti-Müllerian hormone
Aromatase
Aromatase - genetics
Aromatase - metabolism
Chick Embryo
Female
Flounder - metabolism
Glycoproteins - genetics
Glycoproteins - metabolism
Humans
In Situ Hybridization
Japanese flounder
Male
Mice
Molecular Sequence Data
Müllerian inhibiting substance
Ovary - embryology
Ovary - metabolism
RNA, Messenger - metabolism
Sex differentiation
Teleost
Testicular Hormones - genetics
Testicular Hormones - metabolism
Testis - embryology
Testis - metabolism
Teleost
Anti-Müllerian hormone
Müllerian inhibiting substance
Japanese flounder
Sex differentiation
Aromatase
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Summary:Müllerian inhibiting substance (MIS), also known as anti-Müllerian hormone, is a glycoprotein belonging to transforming growth factor β superfamily. In mammals, MIS is responsible for regression of Müllerian ducts, anlagen of the female reproductive ducts, in the male fetus. However, the role of MIS in gonadal sex differentiation of teleost fishes, which do not have the Müllerian ducts, has yet to be clarified. To address the role of MIS on gonadal sex differentiation in fishes, we isolated a MIS cDNA from the Japanese flounder testis and examined the expression pattern of MIS mRNA in gonads of both sexes during sex differentiation period. In this study, we present the first demonstration of sexually dimorphic expression of MIS mRNA during sex differentiation in teleost fishes, similarly to amniote vertebrates which possess the Müllerian ducts.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2004.07.162