High-Resolution Methods for Diagnosing Cartilage Damage In Vivo

Advances in current clinical modalities, including magnetic resonance imaging and computed tomography, allow for earlier diagnoses of cartilage damage that could mitigate progression to osteoarthritis. However, current imaging modalities do not detect submicrometer damage. Developments in in vivo or...

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Published inCartilage Vol. 7; no. 1; pp. 39 - 51
Main Authors Novakofski, Kira D., Pownder, Sarah L., Koff, Matthew F., Williams, Rebecca M., Potter, Hollis G., Fortier, Lisa A.
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.01.2016
Subjects
CT
MRI
imaging
cartilage
multiphoton microscopy
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Summary:Advances in current clinical modalities, including magnetic resonance imaging and computed tomography, allow for earlier diagnoses of cartilage damage that could mitigate progression to osteoarthritis. However, current imaging modalities do not detect submicrometer damage. Developments in in vivo or arthroscopic techniques, including optical coherence tomography, ultrasonography, bioelectricity including streaming potential measurement, noninvasive electroarthrography, and multiphoton microscopy can detect damage at an earlier time point, but they are limited by a lack of penetration and the ability to assess an entire joint. This article reviews current advancements in clinical and developing modalities that can aid in the early diagnosis of cartilage injury and facilitate studies of interventional therapeutics.
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ISSN:1947-6035
1947-6043
DOI:10.1177/1947603515602307