2D DIGE of the cerebrospinal fluid proteome in neurological diseases

2D DIGE is a promising approach to comparative proteome analysis known for a high sensitivity and high reproducibility compared with classical 2DE techniques. It offers new possibilities for the detection of cerebrospinal fluid (CSF) biomarkers in neurological diseases, such as dementia, amyotrophic...

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Bibliographic Details
Published inExpert review of proteomics Vol. 7; no. 1; pp. 29 - 38
Main Authors Tumani, Hayrettin, Lehmensiek, Vera, Lehnert, Stefan, Otto, Markus, Brettschneider, Johannes
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 01.02.2010
Expert Reviews Ltd
Informa Healthcare
Subjects
2D DIGE
biomarker
Cerebrospinal fluid
Cerebrospinal Fluid Proteins - analysis
Diagnosis
Electrophoresis, Gel, Two-Dimensional - methods
Humans
Innovations
Medical examination
Methods
Nervous system diseases
Nervous System Diseases - cerebrospinal fluid
neurological disease
proteome
Proteome - analysis
Proteomics
Proteomics - methods
Germany
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Summary:2D DIGE is a promising approach to comparative proteome analysis known for a high sensitivity and high reproducibility compared with classical 2DE techniques. It offers new possibilities for the detection of cerebrospinal fluid (CSF) biomarkers in neurological diseases, such as dementia, amyotrophic lateral sclerosis or multiple sclerosis. We review the first studies using 2D DIGE for analysis of the CSF proteome in neurological diseases and discuss advantages, as well as drawbacks, of the methodological approach with special emphasis on CSF-related aspects.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1478-9450
1744-8387
DOI:10.1586/epr.09.99