BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients

• Published in: Critical reviews in oncology/hematology Vol. 156; p. 103118
• Main Authors: Malapelle, Umberto, Rossi, Giulio, Pisapia, Pasquale, Barberis, Massimo, Buttitta, Fiamma, Castiglione, Francesca, Cecere, Fabiana Letizia, Grimaldi, Antonio Maria, Iaccarino, Antonino, Marchetti, Antonio, Massi, Daniela, Medicina, Daniela, Mele, Fabio, Minari, Roberta, Orlando, Elisabetta, Pagni, Fabio, Palmieri, Giuseppe, Righi, Luisella, Russo, Alessandro, Tommasi, Stefania, Vermi, William, Troncone, Giancarlo
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.12.2020
• Subjects: BRAF; Lung cancer; Melanoma; Precision medicine; Predictive molecular pathology; BRAF; Precision medicine; Predictive molecular pathology; Lung cancer; Melanoma
• ISSN: 1040-8428; 1879-0461
• DOI: 10.1016/j.critrevonc.2020.103118

[Display omitted] In the era of personalized medicine, BRAF mutational assessment is mandatory in advanced-stage melanoma and non-small cell lung cancer (NSCLC) patients. The identification of actionable mutations is crucial for the adequate management of these patients. To date various drugs have been implemented in clinical practice. Similarly, various methods may be adopted for the identification of BRAF mutations. Here, we briefly review the current literature on BRAF in melanoma and NSCLC, focusing attention in particular on the different methods and drugs adopted in these patients. In addition, an overview of the real-world practice in different Italian laboratories with high expertise in molecular predictive pathology testing is provided.