Effectivity of a strategy in elderly AML patients to reach allogeneic stem cell transplantation using intensive chemotherapy: long-term survival is dependent on complete remission after first induction therapy

Highlights • Results of a strategy to bring all elderly AML patients to transplant are shown. • 32% of patients starting with intensive chemotherapy reach transplant. • Long-term survival is only observed in patients achieving CR after 1st induction. • Reasons of failure of the strategy may help dev...

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Published inLeukemia research Vol. 46; pp. 45 - 50
Main Authors von dem Borne, P.A, de Wreede, L.C, Halkes, C.J.M, Marijt, W.A.F, Falkenburg, J.H.F, Veelken, H
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.07.2016
Subjects
Aged
Algorithms
Allogeneic
AML
Chemotherapy
Disease-Free Survival
Hematology, Oncology and Palliative Medicine
Humans
Induction Chemotherapy - methods
Leukemia, Myeloid, Acute - mortality
Leukemia, Myeloid, Acute - therapy
Middle Aged
Prospective Studies
Remission Induction - methods
Stem cell transplantation
Stem Cell Transplantation - methods
Survival Rate
Transplantation, Homologous
Treatment Outcome
AML
chemotherapy
allogeneic
stem cell transplantation
Allogeneic
Stem cell transplantation
Chemotherapy
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Summary:Highlights • Results of a strategy to bring all elderly AML patients to transplant are shown. • 32% of patients starting with intensive chemotherapy reach transplant. • Long-term survival is only observed in patients achieving CR after 1st induction. • Reasons of failure of the strategy may help develop new treatment algorithms
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2016.03.010