Treatment of Acute Coronary Syndromes

To the Editor: The results of the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study (Aug. 16 issue) 1 suggest that the addition of clopidogrel to aspirin is beneficial for patients who have acute coronary syndromes without elevation of the ST segment. The inclusion criteria wer...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 346; no. 3; pp. 206 - 208
Main Author Owen, Andrew
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 17.01.2002
Subjects
Acute Disease
Aspirin - therapeutic use
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Drug Therapy, Combination
Hemorrhage - chemically induced
Humans
Meta-Analysis as Topic
Myocardial Ischemia - drug therapy
Platelet Aggregation Inhibitors - therapeutic use
Risk
Ticlopidine - analogs & derivatives
Ticlopidine - therapeutic use
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Summary:To the Editor: The results of the Clopidogrel in Unstable Angina to Prevent Recurrent Events (CURE) study (Aug. 16 issue) 1 suggest that the addition of clopidogrel to aspirin is beneficial for patients who have acute coronary syndromes without elevation of the ST segment. The inclusion criteria were changed after the first 3000 patients had been recruited. This change in the entry criteria during the course of recruitment means that the analysis of the results could be interpreted as a meta-analysis of two separate studies, rather than a single study. If one takes this view, the findings necessarily carry less weight. . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM200201173460313