Systematic discovery of new genes in the Saccharomyces cerevisiae genome

We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for small open reading frames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF co...

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Published inGenome research Vol. 13; no. 2; pp. 264 - 271
Main Authors Kessler, Marco M, Zeng, Qiandong, Hogan, Sarah, Cook, Robin, Morales, Arturo J, Cottarel, Guillaume
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.02.2003
Subjects
Amino Acid Sequence - genetics
Animals
Caenorhabditis elegans Proteins - genetics
Cattle
Chromosome Mapping - methods
Chromosomes, Fungal - genetics
Conserved Sequence - genetics
Drosophila Proteins - genetics
Genes, Fungal - genetics
Genome, Fungal
Humans
Letters
Mice
Molecular Sequence Data
Open Reading Frames - genetics
Proteins - genetics
Saccharomyces cerevisiae - genetics
Sequence Homology, Amino Acid
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Abstract We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for small open reading frames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.
AbstractList We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for small open reading frames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.
We used genome-wide comparative analysis of predicted protein sequences to identify many novel small genes, named smORFs for sm all o pen r eading f rames, within the budding yeast genome. Further analysis of 117 of these new genes showed that 84 are transcribed. We extended our analysis of one smORF conserved from yeast to human. This investigation provides an updated and comprehensive annotation of the yeast genome, validates additional concepts in the study of genomes in silico, and increases the expected numbers of coding sequences in a genome with the corresponding impact on future functional genomics and proteomics studies.
Author Zeng, Qiandong
Morales, Arturo J
Cottarel, Guillaume
Hogan, Sarah
Kessler, Marco M
Cook, Robin
AuthorAffiliation Genome Therapeutics Corporation, Waltham, Massachusetts 02453, USA
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  surname: Kessler
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  givenname: Guillaume
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  fullname: Cottarel, Guillaume
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E-MAIL arturo.morales@genomecorp.com; FAX (781) 398-2476.
Article and publication are at http://www.genome.org/cgi/doi/10.1101/gr.232903.
Corresponding author.
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SubjectTerms Amino Acid Sequence - genetics
Animals
Caenorhabditis elegans Proteins - genetics
Cattle
Chromosome Mapping - methods
Chromosomes, Fungal - genetics
Conserved Sequence - genetics
Drosophila Proteins - genetics
Genes, Fungal - genetics
Genome, Fungal
Humans
Letters
Mice
Molecular Sequence Data
Open Reading Frames - genetics
Proteins - genetics
Saccharomyces cerevisiae - genetics
Sequence Homology, Amino Acid
Title Systematic discovery of new genes in the Saccharomyces cerevisiae genome
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