Increased elasticity of melanoma cells after low-LET proton beam due to actin cytoskeleton rearrangements

• Published in: Scientific reports Vol. 9; no. 1; p. 7008
• Main Authors: Jasińska-Konior, Katarzyna, Wiecheć, Olga, Sarna, Michał, Panek, Agnieszka, Swakoń, Jan, Michalik, Marta, Urbańska, Krystyna, Elas, Martyna
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 07.05.2019; Nature Publishing Group UK
• Subjects: Actin; Actin Cytoskeleton - metabolism; Actin Cytoskeleton - radiation effects; Angiogenesis; Cell Line, Tumor; Cell migration; Cell Movement - radiation effects; Cell Proliferation - radiation effects; Cell Survival - radiation effects; Cytoskeleton; DNA repair; Elasticity - radiation effects; Gene Expression Regulation, Neoplastic - radiation effects; Humans; Melanoma; Melanoma - metabolism; Melanoma - radiotherapy; Melanoma, Cutaneous Malignant; Proton Therapy - methods; Skin Neoplasms - metabolism; Skin Neoplasms - radiotherapy; Up-Regulation; Uveal Neoplasms - metabolism; Uveal Neoplasms - radiotherapy; Vimentin; Vimentin - metabolism

Cellular response to non-lethal radiation stress include perturbations in DNA repair, angiogenesis, migration, and adhesion, among others. Low-LET proton beam radiation has been shown to induce somewhat different biological response than photon radiation. For example, we have shown that non-lethal d...