Isometamidium sensitivity of Trypanosoma congolense stocks from cattle in West Africa tested in mice and the drug incubation infectivity test

Four Trypanosoma ( T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kénédougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation in...

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Published inActa tropica Vol. 97; no. 1; pp. 108 - 116
Main Authors Knoppe, Tanja Nikola, Bauer, Burkhard, McDermott, John J., Peregrine, Andrew S., Mehlitz, Dieter, Clausen, Peter-Henning
Format Journal Article
LanguageEnglish
Published Amsterdam Elsevier B.V 2006
Elsevier
Subjects
Animals
Biological and medical sciences
Burkina Faso
Cattle
Drug incubation infectivity test
Drug Resistance
Drug sensitivity
General aspects
Isometamidium chloride
Medical sciences
Mice
Murinae
Phenanthridines - pharmacology
Trypanocidal Agents - pharmacology
Trypanosoma congolense
Trypanosoma congolense - drug effects
Trypanosoma congolense - isolation & purification
Trypanosoma congolense - pathogenicity
Trypanosomiasis, African - parasitology
Trypanosomiasis, Bovine - parasitology
West Africa
Burkina Faso
Africa
Isometamidium chloride
Mice
Drug incubation infectivity test
Burkina Faso
Drug sensitivity
Trypanosoma congolense
Kinetoplastida
Drug
Protozoa
Bovine
Rodentia
Biological activity
Vertebrata
Sensitivity
Mammalia
Mouse
Animal
Infectivity
Isometamidium chloride: Drug sensitivity
Parasiticide
Tropical medicine
Artiodactyla
Ungulata
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Summary:Four Trypanosoma ( T.) congolense reference clones with known isometamidium sensitivity and 16 T. congolense stocks from cattle in Kénédougou in south-western Burkina Faso, an area with known history of drug resistance, were characterised with the standard mouse test (SMT) and the drug incubation infectivity test (DIIT). All field stocks from Kénédougou were resistant to 1.0 mg/kg bw isometamidium in the SMT. Fourteen stocks (87.5%) also proved to be refractory to 10 mg/kg bw. Testing with the DIIT confirmed the results of the SMT. By comparison to reference clones, all the Kénédougou populations expressed high levels of resistance to isometamidium.
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ISSN:0001-706X
1873-6254
DOI:10.1016/j.actatropica.2005.09.008