TROPISETRON FOR POSTOPERATIVE NAUSEA AND VOMITING IN PATIENTS AFTER GYNAECOLOGICAL SURGERY
In a double-blind study, we have compared the prophylactic antiemetic effect of tropisetron 5 mg (Navoban, a 5-HT3 receptor antagonist) with that of placebo, both given as a short i.v. infusion approximately 15 min before wound closure in patients undergoing gynaecological surgery. Perioperative ana...
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Published in | British Journal of Anaesthesia Vol. 71; no. 5; pp. 677 - 680 |
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Main Authors | , , |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Oxford
Elsevier Ltd
01.11.1993
Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | In a double-blind study, we have compared the prophylactic antiemetic effect of tropisetron 5 mg (Navoban, a 5-HT3 receptor antagonist) with that of placebo, both given as a short i.v. infusion approximately 15 min before wound closure in patients undergoing gynaecological surgery. Perioperative anaesthetic care was standardized and patients were observed for at least 24 h after operation, The 35 patients given tropisetron and 34 given placebo treatment were well matched for characteristics. Vomiting occurred in 26% of tropisetron-treated patients, compared with 59% of placebo-treated patients (P = 0.006); 69% of tropisetron-treated patients suffered nausea, compared with 88% of placebo-treated patients (P = 0.05). In addition, patients judged the antiemetic treatment with tropisetron as more effective than the placebo treatment (visual analogue score 71 vs 51mm (P = 0.003)). (Br. J. Anaesth. 1993; 71: 677–680) |
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Bibliography: | istex:7BEFE66070E2EC7E8E221F7FDDAAB1AFA068B669 Correspondence to P.J.W.Z. ark:/67375/HXZ-K44X1KDG-X ArticleID:71.5.677 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 |
ISSN: | 0007-0912 1471-6771 |
DOI: | 10.1093/bja/71.5.677 |