Virologic and immunologic responses to antiretroviral therapy among HIV-1 and HIV-2 dually infected patients: Case reports from Abidjan, Côte d’Ivoire

• Published in: Journal of clinical virology Vol. 45; no. 1; pp. 72 - 75
• Main Authors: Borget, Marie-Yolande, Diallo, Karidia, Adje-Toure, Christiane, Chorba, Terence, Nkengasong, John N
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.05.2009; Elsevier
• Subjects: Adult; Allergy and Immunology; Anti-HIV Agents - pharmacology; Anti-HIV Agents - therapeutic use; Antiretroviral therapy; Biological and medical sciences; CD4 Lymphocyte Count; Cote d'Ivoire; Dual infection; Enzyme-Linked Immunosorbent Assay; Female; Fundamental and applied biological sciences. Psychology; HIV Infections - drug therapy; HIV Infections - immunology; HIV Infections - virology; HIV Protease Inhibitors - pharmacology; HIV Protease Inhibitors - therapeutic use; HIV-1 - drug effects; HIV-1/HIV-2; HIV-2 - drug effects; Human immunodeficiency virus 1; Human immunodeficiency virus 2; Human viral diseases; Humans; Infectious Disease; Infectious diseases; Male; Medical sciences; Microbiology; Middle Aged; Miscellaneous; Polymerase Chain Reaction; Response to therapy; Reverse Transcriptase Inhibitors - pharmacology; Reverse Transcriptase Inhibitors - therapeutic use; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Virology; Côte d'Ivoire; Africa; Cote d'Ivoire; Dual infection; Response to therapy; Antiretroviral therapy; HIV-1/HIV-2; Immunopathology; Microbiology; HIV-1 virus; Retroviridae; AIDS; Immune deficiency; Lentivirus; Virology; HIV-2 virus; Infection; Virus; Case study; Chemotherapy; Treatment; Viral disease; Antiviral; Human immunodeficiency virus
• ISSN: 1386-6532; 1873-5967
• DOI: 10.1016/j.jcv.2009.03.011

Abstract In four of five HIV-1 and HIV-2 dually infected patients treated with efavirenz-based therapy, viral load was undetectable for HIV-1 only, with limited increase in CD4+ counts. Both viral loads were undetectable and CD4+ counts increased in one patient treated with protease inhibitor regimen. Specific guidelines for treating HIV-dually infected patients are needed that should avoid the use of non-nucleoside reverse transcriptase inhibitors.