BACLOFEN PROLONGS THE ANALGESIC EFFECT OF FENTANYL IN MAN

Pretreatment with baclofen prolonged the duration of fentanyl-induced analgesia from 18 to 30 min in patients undergoing neurosurgical anaesthesia (fentanyl plus nitrous oxide in oxygen). This observation is consistent with a potentiating effect of GABA on opioid analgesia.

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Bibliographic Details
Published inBritish journal of anaesthesia : BJA Vol. 57; no. 10; pp. 954 - 955
Main Authors PANERAI, A.E., MASSEI, R., DE SILVA, E., SACERDOTE, P., MONZA, G., MANTEGAZZA, P.
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.1985
Oxford University Press
Subjects
Adult
Analgesics
Anesthesia, General
Baclofen - administration & dosage
Baclofen - pharmacology
Biological and medical sciences
Drug Synergism
Fentanyl - pharmacology
Humans
Hypophysectomy
Injections, Intramuscular
Injections, Intravenous
Male
Medical sciences
Middle Aged
Neuropharmacology
Nitrous Oxide
Pharmacology. Drug treatments
Preanesthetic Medication
Human
Chemotherapy
Analgesic
Pain
Intravenous administration
Surgery
General anesthesia
Nervous system
Drug interaction
Pretreatment
Nitrogen protoxide
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Summary:Pretreatment with baclofen prolonged the duration of fentanyl-induced analgesia from 18 to 30 min in patients undergoing neurosurgical anaesthesia (fentanyl plus nitrous oxide in oxygen). This observation is consistent with a potentiating effect of GABA on opioid analgesia.
Bibliography:ark:/67375/HXZ-KVBBHWSC-D
ArticleID:57.10.954
Correspondence to A.E.P. (Department of Pharmacology).
istex:5DD2B6820FABE05E15274373C99428335F493A90
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/57.10.954