Symptomatic Vocal Cord Paresis/Paralysis in Infants Operated on for Esophageal Atresia and/or Tracheo-Esophageal Fistula

• Published in: The Journal of pediatrics Vol. 158; no. 6; pp. 973 - 976
• Main Authors: Morini, Francesco, MD, Iacobelli, Barbara D., MD, Crocoli, Alessandro, MD, Bottero, Sergio, MD, Trozzi, Marilena, MD, Conforti, Andrea, MD, Bagolan, Pietro, MD
• Format: Journal Article
• Language: English
• Published: Maryland Heights, MO Mosby, Inc 01.06.2011; Elsevier
• Subjects: abnormal development; Anastomotic Leak; Biological and medical sciences; birth weight; Cohort Studies; Esophageal Atresia - complications; Esophageal Atresia - surgery; Esophagus; fistula; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Gestational Age; Humans; Infant; Infant, Newborn; infants; Malformations; Medical sciences; morbidity; Nervous system (semeiology, syndromes); Nervous system as a whole; Neurology; paralysis; Paralysis - diagnosis; Paralysis - etiology; paresis; pathogenesis; patients; Pediatrics; Prevalence; Retrospective Studies; Risk Factors; surgery; Tracheoesophageal Fistula - complications; Tracheoesophageal Fistula - surgery; Treatment Outcome; Vocal Cord Paralysis - diagnosis; Vocal Cord Paralysis - etiology; Vocal Cords - pathology; Esophageal atresia; VCP; Vocal cord paralysis/paresis; TEF; EA; Tracheo-esophageal fistula; Human; Pediatrics; Diseases of the trachea; Nervous system diseases; Respiratory disease; Motor system disorder; Esophageal disease; Infant; Tracheoesophageal fistula; Symptomatology; Vocal cord paralysis; Paresis; Digestive diseases; Neurological disorder
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/j.jpeds.2010.12.006

Objectives To describe the prevalence and pathogenesis of symptomatic vocal cord paresis/paralysis (VCP) in patients treated for esophageal atresia (EA), tracheo-esophageal fistula (TEF) or both. Study design Retrospective study of all patients treated for EA/TEF in our center (1995 to 2009). Patients with and without symptomatic VCP were compared for gestational age, birth weight, associated anomalies, referrals, long-gap EA (>3cm or 3 vertebral bodies), cervical esophagostomy, anastomotic leakage, length of ventilation, and major cardiac surgery. Prevalence or median (IQR) is reported. Results Of 174 patients, 7 (4%) had symptomatic VCP. Prevalence of referrals (5/7 versus 21/167; P = .0009), long gap (5/7 versus 41/167; P = .0146), previous cervical esophagostomy (5/7 versus 7/167; P < .0001), and anastomotic leakage (3/7 versus 10/167; P = .0097) was higher, and ventilation longer (8.5 days [7.0 to 15.5] versus 6.0 days (5.0 to 7.0); P = .0072) in patients with VCP. Conclusions In infants treated for EA/TEF, VCP should be ruled out in case of persistent respiratory morbidity or, when present, cautiously monitored. Surgical risk factors should be actively controlled. Further studies are needed to define the prevalence of acquired and congenital VCP in patients with EA/TEF.