Biological Applications of Silica-Based Nanoparticles

• Published in: Magnetochemistry Vol. 8; no. 10; p. 131
• Main Authors: Bruckmann, Franciele da Silva, Nunes, Franciane Batista, Salles, Theodoro da Rosa, Franco, Camila, Cadoná, Francine Carla, Bohn Rhoden, Cristiano Rodrigo
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.10.2022
• Subjects: Acid leaching; Analysis; Apoptosis; Biocompatibility; Biomedical engineering; Biomedical materials; Cytotoxicity; Drug delivery systems; Drugs; Identification and classification; magnetic nanoparticles; Magnetic properties; Magnetic resonance imaging; Mechanical properties; Methods; Microemulsions; Morphology; multifunctional systems; nanocarriers; Nanoparticles; Oxidative stress; Particle size; Signal transduction; Silica; Silicon dioxide; Thermal stability; Vehicles; Brazil
• ISSN: 2312-7481; 2312-7481
• DOI: 10.3390/magnetochemistry8100131

Silica nanoparticles have been widely explored in biomedical applications, mainly related to drug delivery and cancer treatment. These nanoparticles have excellent properties, high biocompatibility, chemical and thermal stability, and ease of functionalization. Moreover, silica is used to coat magnetic nanoparticles protecting against acid leaching and aggregation as well as increasing cytocompatibility. This review reports the recent advances of silica-based magnetic nanoparticles focusing on drug delivery, drug target systems, and their use in magnetohyperthermia and magnetic resonance imaging. Notwithstanding, the application in other biomedical fields is also reported and discussed. Finally, this work provides an overview of the challenges and perspectives related to the use of silica-based magnetic nanoparticles in the biomedical field.