The association of ABO blood group with the asymptomatic COVID-19 cases in India

The COVID-19 pandemic resulted in multiple waves of infection worldwide. The large variations in case fatality rate among different geographical regions suggest that the human susceptibility against this virus varies substantially. Several studies from different parts of the world showed a significa...

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Published inTransfusion and apheresis science Vol. 60; no. 6; p. 103224
Main Authors Singh, Prajjval Pratap, Srivastava, Abhishek K., Upadhyay, Sudhir K., Singh, Ashish, Upadhyay, Shashank, Kumar, Pradeep, Rai, Vandana, Shrivastava, Pankaj, Chaubey, Gyaneshwer
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.12.2021
Subjects
ABO Blood-Group System - blood
Asymptomatic
Blood group
Coronavirus
COVID-19
COVID-19 - blood
COVID-19 - epidemiology
Disease Susceptibility
Female
Humans
India
India - epidemiology
Male
Pandemics
Risk Factors
SARS-CoV-2 - metabolism
Severity of Illness Index
India
COVID-19
Blood group
Asymptomatic
Coronavirus
India
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Summary:The COVID-19 pandemic resulted in multiple waves of infection worldwide. The large variations in case fatality rate among different geographical regions suggest that the human susceptibility against this virus varies substantially. Several studies from different parts of the world showed a significant association of ABO blood group and COVID-19 susceptibility. It was demonstrated that individuals with blood group O are at the lower risk of coronavirus infection. To establish the association of ABO blood group in SARS-CoV-2 susceptibility, we for the first time analysed SARS-CoV-2 neutralising antibodies among 509 individuals, collected from three major districts of Eastern Uttar Pradesh region of India. Interestingly, we found neutralising antibodies in a significantly higher percentage of people with blood group AB (0.36) followed by B (0.31), A (0.22) and lowest in people with blood group O (0.11). We further estimated that people with blood group AB are at comparatively higher risk of infection than other blood groups. Thus, among the asymptomatic SARS-CoV-2 recovered people blood group AB has highest, whilst individuals with blood group O has lowest risk of infection.
Bibliography:Equal first author contribution.
The full author details of Serosurveillance Consortium BHU has been given in Supplementary text.
ISSN:1473-0502
1878-1683
1473-0502
DOI:10.1016/j.transci.2021.103224