Psychological distress in men with prostate cancer receiving adjuvant androgen-deprivation therapy

• Published in: Urologic oncology Vol. 31; no. 3; pp. 352 - 358
• Main Authors: Saini, Andrea, M.D, Berruti, Alfredo, M.D., Ph.D, Cracco, Cecilia, M.D, Sguazzotti, Erica, Psy.D, Porpiglia, Francesco, M.D., Ph.D, Russo, Lucianna, M.D, Bertaglia, Valentina, M.D, Picci, Rocco Luigi, M.D, Negro, Manuela, Psy.D, Tosco, Alessandra, R.N, Campagna, Sara, R.N, Scarpa, Roberto Mario, M.D., Ph.D, Dogliotti, Luigi, M.D., Ph.D, Furlan, Pier Maria, M.D., Ph.D, Ostacoli, Luca, M.D
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2013
• Subjects: Aged; Aged, 80 and over; Androgen Antagonists - adverse effects; Androgen-deprivation therapy; Anxiety - chemically induced; Body Image - psychology; Depression; Depression - chemically induced; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Neoplasm Grading; Outcome Assessment (Health Care); Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - pathology; Prostatic Neoplasms - psychology; Quality of life; Quality of Life - psychology; Sleep Wake Disorders - chemically induced; Stress, Psychological - etiology; Urology; Depression; Androgen-deprivation therapy; Prostate cancer; Quality of life
• ISSN: 1078-1439; 1873-2496
• DOI: 10.1016/j.urolonc.2011.02.005

Abstract Objectives To compare the occurrence of depression, anxiety, self body image perception, sleep disturbances, and diminished quality of life in prostate cancer patients undergoing adjuvant androgen-deprivation therapy (ADT) as opposed to patients in follow-up alone. Methods and materials Hospital Anxiety and Depression Scale, Pittsburgh Sleep Quality Index, Restless Legs Syndrome Study Group essential diagnostic criteria, Body Image Scale and Functional Assessment of Cancer Therapy Prostate were administered to consecutive prostate cancer patients who underwent radical prostatectomy or radiation therapy and are presently either under adjuvant ADT or included in a follow-up program. Results Of the 103 patients enrolled, 49 (47.6%) were receiving adjuvant ADT and 54 (52.4%) were not. Compared with the controls, the patients undergoing ADT showed higher levels of depression ( P = 0.002), worse self body image perception ( P = 0.001), worse quality of life ( P = 0.0001) and worse sleep quality ( P = 0.04). ADT was significantly associated with depression at multivariate analysis after adjustment for age, stage, Gleason score, as well as demographic and social variables ( P = 0.001). Depression scores showed a strong inverse correlation with quality of life scores ( P < 0.01). Conclusions Adjuvant ADT is associated with depression, worse quality of life, and altered self body image in prostate cancer patients.