Puberty suppression and executive functioning: An fMRI-study in adolescents with gender dysphoria

• Published in: Psychoneuroendocrinology Vol. 56; pp. 190 - 199
• Main Authors: Staphorsius, Annemieke S, Kreukels, Baudewijntje P.C, Cohen-Kettenis, Peggy T, Veltman, Dick J, Burke, Sarah M, Schagen, Sebastian E.E, Wouters, Femke M, Delemarre-van de Waal, Henriëtte A, Bakker, Julie
• Format: Journal Article Web Resource
• Language: English
• Published: England Elsevier Ltd 01.06.2015; Elsevier
• Subjects: Adolescent; Adolescents; Diagnostic and Statistical Manual of Mental Disorders; Endocrinology & Metabolism; Executive Function; Female; fMRI; Functional Laterality - physiology; Gender dysphoria; Gender Dysphoria - pathology; Gender Dysphoria - physiopathology; Gender Dysphoria - psychology; Gender Dysphoria/pathology/physiopathology/psychology; Gonadotropin releasing hormone analog; Gonadotropin-Releasing Hormone - therapeutic use; Humans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Neurosciences & behavior; Neurosciences & comportement; Prefrontal Cortex - physiopathology; Psychiatry; Psychomotor Performance; Puberty - psychology; Reaction Time - physiology; Sciences sociales & comportementales, psychologie; Sex difference; Sex Differentiation; Social & behavioral sciences, psychology; Tower of London; fMRI; Gonadotropin releasing hormone analog; Tower of London; Adolescents; Gender dysphoria; Sex difference
• ISSN: 0306-4530; 1873-3360; 1873-3360
• DOI: 10.1016/j.psyneuen.2015.03.007

Highlights • Puberty suppression does not have an effect on ToL performance. • Adolescent boys and girls show sex differences in ToL-load related brain activations. • GnRHa treated participants with GD show sex differences similar to the control groups. • For the untreated participants with GD no significant sex differences were found. • Pubertal hormones induced sex-atypical brain activations in adolescents with GD.